Looking the best way to go from Siem Reap to Ho Chi Minh? Vietnam and Cambodia are pretty close and the two countries share 3 international border crossings.
There are many tourists in Cambodia from Vietnam and vice versa. And among all the cities of Cambodia, Phnom Penh and Siem Reap are the two cites that people from Vietnam tend to visit most.
Phnom Penh is the capital and the largest city in Cambodia. It is also a famous destination to the tourists for many traveling attractions. While Siem Reap is another famous tourist city of Cambodia with also a lot of well-known travel sites.
Although the distant between the two countries is close, the transportation is somehow complicated and time-consuming. There are different ways either overland or by plane to travel between Vietnam and Cambodia, not only by plane like the most of other countries. Unfortunately, there is no train to travel between Ho Chi Minh and Cambodia.
And obviously, you need a tourist visa to travel between the two countries. Somehow you can get it at the airport when travelling by plane but you’d better to prepare it in advance.
Following are the detailed information about the transportation from Siem Reap to Ho Chi Minh:

From Siem Reap to Ho Chi Minh by Plane

This is the most expensive but the most straightforward and fastest way to travel directly from Siem Reap to Ho Chi Minh.
The average flight price for a trip from Siem Reap to Ho Chi Minh is $256.
To get a cheap flight, you can go and search multiple sites online, collect the airlines’ data and choose the suitable one. The ticket price can be adjusted based on the time you book your flight, so decide to book smartly and you can save some money to travel. People say that Tuesdays, Wednesdays, and Saturdays are best days to book your flight tickets and the flights those days are always cheaper than the other.
The average flight time is an hour and 15 minutes.
There are several airlines for you to choose, each airline offer different levels of service with different price. Among airlines providing flights from Siem Reap to HO CHI MINH, Cambodia Angkor Air is the most popular, it provides 51% of the non-stop flights between the two cities.
The other airlines offering flights from Siem Reap to Ho Chi Minh are Lebanese Air, Vietnam Airlines, Jetstar Asia, AirAsia, Cathay Pacific, China Southern, Thai AirAsia, Xiamen, Malaysia, Asiana, Bangkok, Lao Airlines, Singapore Airlines, Thai, Vietjet Air.

From Siem Reap to Ho Chi Minh by Bus

There are two options for you to choose, direct bus from Siem Reap to Ho Chi Minh or bus tour from Siem Reap to Phnom Penh then continue with another bus from Phnom Penh to Ho Chi Minh.
One of the few companies offering direct buses from Siem Reap to Ho Chi Minh is Mekong Express. Their bus departs at 7:00 and arrives at 19:00. Along the journey, it stops at Phnom Penh in 30 minutes. The ticket price is from $25.
Add: 287, Phsar Chas (Old Market), Siem Reap
Tel: (855) 012 559 447
Email: mekongtoursspp@yahoo.com
Web: mekongvietnam.com
The other buses from Siem Reap to Phnom Penh starts at 7:00 or 12:30 and arrives in Phnom Penh after about 5 hours. The ticket price may be from $4-9. Then you can choose from a lot of buses from Phnom Penh to Ho Chi Minh.

From Siem Reap to Ho Chi Minh by Boat

Not many people travel from Siem Reap to Ho Chi Minh because there are not wide options.
If you want to travel by speedboat, your journey has to be divided into small parts. First, you have to take a tuktuk or taxi from Siem Reap to Chong Kneas, then take a speed boat there to Phnom Penh. You can buy ticket of a Mekong Explore’s boat. It departs at 7:30 every day and you can get to Phnom Penh after 6 hours. The ticket price is $28. Then you have to stay overnight in Phnom Penh until the next day to take another speed boat of Hang Chau departing daily at 12:30 pm and you can get to Chau Doc after 3.5 hours, the ticket price is $28.60. The final part of the journey can be done by a bus or taxi from Chau Doc to Ho Chi Minh.
Another idea if you want to travel from Siem Reap to Ho Chi Minh City while enjoying the charming scenes along the river is getting a Mekong cruise tour of Heritage Line. They offer The Lost Civilization which is an 8 days – 7 nights cruise tour from Siem Reap to Ho Chi Minh City. Following is the general program timeline:
Day 1: Siem Reap – Tonle River
Day 2: Kampong Chhnang – Kam. Tralach – Kampong Cham
Day 3: Kampong Cham – Okhna Tey – Phnom Penh
Day 4: Phnom Penh
Day 5: Phnom Penh – Border Crossing – Tan Chau
Day 6: Tan Chau – An My Hung – Sa Dec
Day 7: Binh Thanh Island – Cai Be – My Tho
Day 8: My Tho – Sai Gon
The schedule can be different from Siem Reap to Phnom Penh depending on the low water and high water season. The price is from $1,000 and depends on the levels and the seasons. For more information, you can email us sales@asiajourneytravel.com to be provided the suitable program.